Fruit complex

Fruit Complex – Salvestrols are protective substances that protect plants from viruses, bacteria, mould, insects and UV light. The plants only form them in larger quantities when the substances are needed. Conventional vegetables, fruits and herbs are sprayed with „pesticides“. As a result, the sprayed plants produce only a few protective substances and are therefore poor in salvestrols.

On the other hand, unsprayed, i.e. organically cultivated plants produce plenty of salvestrole to protect themselves from attacks. Researchers have found that the human body has naturally been using these substances supplied with food to maintain health for ages. fruit complex

What research led to the discovery of Salvestrole?

In the 1990s, Professor Dan Burke’s research group at Aberdeen University discovered a new cytochrome P450 enzyme called CYP1B1 in tumour cells. It causes the body to detoxify metabolic products and foreign toxins such as carcinogens, plant toxins, anti-cancer drugs and others when an activating substance is added. The researchers now have a lot of scientific evidence that the increased presence of this enzyme is a common characteristic of almost all cancers. In the future, the detection of CYP1B1 in cells will make it possible to detect cancer at an early stage. fruit complex

Professor Burke and his team assume that the CYP1B1 enzyme is „switched on“ in „degenerate“ cells to eliminate them. However, the reaction with the enzyme CYP1B1 converts them into toxic substances that lead to the programmed cell death of the tumour cell. Today’s cytostatic drugs such as docetaxel, ellipticin, mitoxantrone and tamoxifen cause severe side effects because they also attack healthy cells. The detection of substances that are toxic only to tumour cells is a major advance in the fight against cancer.

What does this discovery mean for cancer research?

Professor Burke was appointed to Montford University in Leicester, where he met the clinical chemist Professor Gerry Potter, an expert in the development of anticancer drugs. After the discovery of the enzyme CYP1B1, he developed the first synthetic prodrug that causes tumour cells to die in cooperation with the enzyme.

Cancer-inhibiting salvestrole

In 2002, as a result of research, it was proven that resveratrol – a natural phytoestrogen, which is known as in grapes, red wine, peanuts, currants, plums, tomatoes and pines – is converted by the enzyme CYP1B1 into the tyrosine kinase inhibitor piceatannol, which is fatal for tumour cells. In the meantime, English researchers have found more than 20 plant substances – bioflavonoids, carboxylic acids, stilbenes and stilbenoids – which share the property of killing cancer cells with the help of the enzyme CYP1B1. These substances are not chemically related, but have an identical substructure that causes the mechanism of action.